FITC标记的突触结合蛋白1抗体
产品名称： FITC标记的突触结合蛋白1抗体
英文名称： Anti-Synaptotagmin 1/FITC
产品编号： HZ-4172R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Synaptotagmin 1/FITC Conjugated antibody
FITC标记的突触结合蛋白1抗体
| 英文名称 | Anti-Synaptotagmin 1/FITC |
| 中文名称 | FITC标记的突触结合蛋白1抗体 |
| 别 名 | DKFZp781D2042; P65; SVP65; Synaptotagmin I; SYT1_HUMAN; Synaptotagmin II; Synaptotagmin IV; Synaptotagmin V; SYT 1; SYT; SYT1; SYT2; SYT3; SYT4; SYT5; SytI. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 神经生物学 信号转导 细胞粘附分子 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Synaptotagmin 1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Function: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). Subunit: Homotetramer (Probable). Interacts with SCAMP5, STON2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25. Subcellular Location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules. Similarity: Belongs to the synaptotagmin family. Contains 2 C2 domains. Database links: Entrez Gene: 6857 Human Entrez Gene: 20979 Mouse Entrez Gene: 25716 Rat Omim: 185605 Human SwissProt: P21579 Human SwissProt: P46096 Mouse SwissProt: P21707 Rat Unigene: 310545 Human Unigene: 289702 Mouse Unigene: 216272 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
突触小泡是突触囊泡的整体膜蛋白，被认为是囊泡运输和胞吐过程中的CA（2 +）传感器。钙结合突触蛋白参与突触的神经递质释放。第一个C2结构域介导了Ca~（2+）依赖的磷脂结合。第二个C2结构域介导与StnON 2的相互作用。突触小球蛋白在突触活跃区突触囊泡的运输过程中可能具有调节作用。它结合酸性磷脂的特异性，需要酸性头基团和双酰基骨架的存在。还报道了突触蛋白与钙激活蛋白激酶C受体（2）依赖性的相互作用。它可以结合至少三个额外的蛋白质在CA（2 +）-独立的方式，这些是Nexxin，Sythin和AP2。