Product Information
 


    

        

            

            
Product Name
            
            

            
Cat#
            
            

            
Size
            
            

            
Price（¥）
            
        
        

            

            
Recombinant Human Bone Morphogenetic Protein 2 (Human BMP-2)
            
            

            
92051ES10
            
            

            
10 μg
            
            

            
1855.00
            
        
        

            

            
92051ES60
            
            

            
100 μg
            
            

            
10215.00
            
        
        

            

            
92051ES76
            
            

            
500 μg
            
            

            
26545.00
            
        
    


 
Product Description
 
Bone morphogenetic protein 2 (BMP-2), is a member of the BMP subgroup, some of which belong to the TGF-beta superfamily (BMP2-7). It plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration. Mature human BMP-2 shares 100% aa sequence identity with mouse and rat BMP-2. It shares 85% aa sequence identity with human BMP-4 and less than 51% with other BMPs. Normal bone formation is a prolonged process that is carefully regulated and involves sequential expression of growth regulatory factors by osteoblasts as they proliferate and ultimately differentiate. Since this orderly sequence of gene expression by osteoblasts suggests a cascade effect, and BMP-2 is capable of initiating and maintaining this effect. BMP-2 also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells, and is required for cardiac contractility.
 
Product Properties
 


    

        

            

            
Synonyms
            
            

            
BDA2, BMP2, BMP-2, BMP-2A, SSFSC
            
        
        

            

            
Accession
            
            

            
P12643
            
        
        

            

            
GeneID
            
            

            
650
            
        
        

            

            
Source
            
            

            
E.coli-derived human BMP-2, Gln283-Arg396, with an N-terminal Met.
            
        
        

            

            
Molecular Weight
            
            

            
Approximately 26.0 kDa.
            
        
        

            

            
AA Sequence
            
            

            
MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
            
        
        

            

            
Tag
            
            

            
None
            
        
        

            

            
Physical Appearance
            
            

            
Sterile Filtered White lyophilized (freeze-dried) powder.
            
        
        

            

            
Purity
            
            

            
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