FITC标记的受体辅助蛋白1抗体
产品名称： FITC标记的受体辅助蛋白1抗体
英文名称： Anti-REEP1/FITC
产品编号： HZ-11752R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-REEP1/FITC Conjugated antibody
FITC标记的受体辅助蛋白1抗体
| 产品编号 | bs-11752R-FITC |
| 英文名称 | Anti-REEP1/FITC |
| 中文名称 | FITC标记的受体辅助蛋白1抗体 |
| 别 名 | C2orf23; Chromosome 2 open reading frame 23; FLJ13110; Receptor accessory protein 1; Receptor expression-enhancing protein 1; Reep1; REEP1_HUMAN; SPG31. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞膜受体 G蛋白偶联受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human REEP1 (53-150aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Transport of G protein-coupled receptors (GPCRs) to the cell surface membrane is critical for receptor-ligand recognition. Mammalian GPCR odorant receptors (ORs), when heterologously expressed in cells, are poorly expressed on the cell surface. REEP1 (receptor expression-enhancing protein 1), is a 201 amino acid multi-pass mitochondrion membrane protein that belongs to the DP1 family. REEP1 interacts with odorant receptor proteins and may enhance the cell surface expression of odorant receptors. Mutations in the REEP1 gene are the third most common cause of hereditary spastic paraplegia (HSP) after spastin and atlastin gene mutations. Mutations in the REEP1 gene also cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. The REEP1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana and rice, and maps to human chromosome 2p11.2. Function: May enhance the cell surface expression of odorant receptors. Subunit: Interacts with SPAST and ATL1; it preferentiallyinteracts with SPAST isoform 1. Interacts (via C-terminus) withmicrotubules. Interacts with odorant receptor proteins Subcellular Location: Membrane. Mitochondrion membrane; Multi-passmembrane protein. Endoplasmic reticulum. Post-translational modifications: Belongs to the DP1 family. DISEASE: Defects in REEP1 are the cause of spastic paraplegia autosomal dominant type 31 (SPG31) [MIM:610250]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Similarity: Belongs to the DP1 family. Database links: Entrez Gene: 65055 Human Entrez Gene: 52250 Mouse Entrez Gene: 362384 Rat Omim: 609139 Human SwissProt: Q9H902 Human SwissProt: Q8BGH4 Mouse SwissProt: D4A193 Rat Unigene: 368884 Human Unigene: 146332 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
G蛋白偶联受体（GPCRs）对细胞表面膜的转运是受体配体识别的关键。哺乳动物GPCR气味受体（OR）在细胞中异源表达时，在细胞表面表达不佳。ReEP1（受体表达增强蛋白1）是属于DP1家族的201氨基酸多程线粒体膜蛋白。ReEP1与气味受体蛋白相互作用，并可增强气味受体的细胞表面表达。ReEP1基因突变是SPASTIN和ATLASTIN基因突变后遗传性痉挛性截瘫（HSP）的第三个最常见的原因。ReEP1基因的突变也引起痉挛性截瘫常染色体显性遗传31型，即神经退行性疾病。ReEP1基因在黑猩猩、狗、牛、小鼠、大鼠、鸡、斑马鱼、A.thaliana和水稻中保存，并映射到人类染色体2P11.2。